Marmara Üniversitesi Açık Arşiv Sistemi

Hypothalamic obesity in children: Pathophysiology to clinical management

Basit öğe kaydını göster Haliloǧlu, Belma 2016-03-15T16:03:30Z 2016-03-15T16:03:30Z 2015
dc.identifier.issn 0334018X
dc.description.abstract Hypothalamic obesity (HyOb) is a complex neuroendocrine disorder caused by damage to the hypothalamus, which results in disruption of energy regulation. The key hypothalamic areas of energy regulation are the ARC (arcuate nucleus), the VMH (ventromedial hypothalamus), the PVN (paraventriculer nuclei) and the LHA (lateral hypothalamic area). These pathways can be disrupted mechanically by hypothalamic tumors, neurosurgery, inflammatory disorders, radiotherapy and trauma or functionally as such seen in genetic diseases. Rapid weight gain and severe obesity are the most striking features of HyOb and caused by hyperphagia, reduced basal metabolic rate (BMR) and decreased physical activity. HyOb is usually unresponsive to diet and exercise. Although, GLP-1 and its anologs seem to be a new agent, there is still no curative treatment. Thus, prevention is of prime importance and the clinicians should be alert and vigilant in patients at risk for development of HyOb. © 2015 by De Gruyter. en_US
dc.language.iso eng en_US
dc.relation.isversionof 10.1515/jpem-2014-0512 en_US
dc.rights info:eu-repo/semantics/restrictedAccess en_US
dc.subject children; craniopharygioma; hypothalamus; obesity en_US
dc.title Hypothalamic obesity in children: Pathophysiology to clinical management en_US
dc.type article en_US
dc.relation.journal Journal of Pediatric Endocrinology and Metabolism en_US
dc.contributor.department Department of Pediatrics, Marmara University Hospital en_US
dc.identifier.volume 28 en_US
dc.identifier.issue 5-6 en_US
dc.identifier.startpage 503 en_US
dc.identifier.endpage 513 en_US

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