Marmara Üniversitesi Açık Arşiv Sistemi

Effects of systemic Thalidomide and intracerebroventricular Etanercept and Infliximab administration in a Streptozotocin induced dementia model in rats

Basit öğe kaydını göster Elçioğlu, Hatice Kübra 2016-04-13T17:28:02Z 2016-04-13T17:28:02Z 2015
dc.identifier.issn 00651281
dc.description.abstract Tumor necrosis factor-alpha (TNF-α) upregulation enhances amyloid β (Aβ) induced neurotoxicity in Alzheimer's disease (AD). Intracerebroventricular streptozotocin (STZ) administration causes pathological changes and cognitive deficits similar to those seen in AD by causing impairment of brain glucose and energy metabolism. Recent reports indicate a protective role of Thalidomide, Etanercept, and Infliximab, all of which have anti-TNF-α activity, against cognitive and neuropathological changes in experimental and clinical studies. We aimed to investigate the protective effects of Thalidomide, Etanercept, and Infliximab in a rat model of intracerebroventricular STZ-induced dementia. Sprague-Dawley rats (250-300. g) were separated to sham (n= 6) and STZ (n= 24) groups. The STZ group was divided into four groups (STZ, STZ-thalidomide, STZ-etanercept, and STZ-infliximab). Morris's water maze (MWM) and passive avoidance (PA) tests were performed. At the end of the third week, brain tissues were obtained. Histopathological analysis, immunohistochemistry, and electron microscopic examinations were done. The improvement performance of the STZ group was significantly reduced in the MWM test (p<. 0.001). Compared with the STZ, STZ-thalidomide, STZ-etanercept, and STZ-infliximab groups had significantly better performance (p<. 0.001, <0.05 and <0.05, respectively) in the MWM test. STZ administration caused a significant decrease in the mean escape latency in PA reflex (p<. 0.001). Thalidomide, Etanercept, and Infliximab were associated with better PA reflexes compared to the STZ group (p<. 0.001 for all). Morphological and immunohistochemical results showed increased neurodegenerative changes compared to sham group. Our findings are in line with the findings reported in the literature and encourage further studies with TNF-α antagonists, in particular Thalidomide. © 2015 Elsevier GmbH. en_US
dc.language.iso eng en_US
dc.relation.isversionof 10.1016/j.acthis.2014.12.002 en_US
dc.rights info:eu-repo/semantics/restrictedAccess en_US
dc.subject Etanercept; Infliximab; Rat dementia model; Streptozotocin; Thalidomide en_US
dc.title Effects of systemic Thalidomide and intracerebroventricular Etanercept and Infliximab administration in a Streptozotocin induced dementia model in rats en_US
dc.type article en_US
dc.contributor.authorID TR17475 en_US
dc.relation.journal Acta Histochemica en_US
dc.contributor.department Department of Pharmacology, School of Pharmacy, Marmara University en_US
dc.identifier.volume 117 en_US
dc.identifier.issue 2 en_US
dc.identifier.startpage 176 en_US
dc.identifier.endpage 181 en_US

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