Aterosklerozun patofizyolojisi ve risk faktörleri
Savaş Tetik, Sermin
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Atherosclerosis and its complications is the leading cause of death both in our country and in the world. Atherosclerosis is a disease that affects the intima layers of medium and large arteries with its typical lesions “atherosclerotic plaques”. Endothelial dysfunction is one of the basic mechanisms in the atherosclerotic process. Classic and newly identified risk factors leading to a decrease in the vasodilator response creates chronic injury. Thus, vasoconstriction composed in endothelium, accumulation of inflammatory cells, smooth muscle cell migration, cytokine production cause the increase of events such as the formation of atherosclerotic plaques. Endothelial dysfunction is not only the first step of the atherosclerotic plaque formation process, but also cause triggering of atherogenic events cracking and the growth of plaque. The most important factor that plays a role in the pathogenesis of atherosclerosis is hypercholesterolemia. Epidemiological studies indicate that along many genetic and environmental factors, increased serum cholesterol levels is enough alone for development of atherosclerosis in the absence of other known risk factors. In this study, lipoproteins that are considered to contribute formation of the pathogenesis of atherosclerosis by creating foam cells were examined and it is aimed to evaluate this phenomenon considering the many parameters joining it.