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Formulation and evaluation of orally dispersible tablets of Chlorpheniramine Maleate by fusion method

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dc.contributor.author DAVE, Vivek
dc.contributor.author YADAV, Renu Bala
dc.contributor.author AHUJA, Richa
dc.contributor.author SAHU, Atul Kumar
dc.date.accessioned 2018-03-05T10:39:12Z
dc.date.available 2018-03-05T10:39:12Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/11424/6323
dc.description.abstract Many conventional dosage form comes in market to achieve their therapeutic value as it administered through the given route. But sometimes People feel trouble in swallowing of conventional dosage forms like tablet and capsule without taking water or due to lack availability of water during long journey. In these cases, rapidly disintegrating tablets in oral cavity are paid attention nowadays. These are known as orally dispersible tablets which disintegrate in mouth as put on tongue resulting in release of drug which dissolve and disperse in saliva. Drug rapidly converts into solution from solid form resulting in rapid absorption and onset of action. After formulation, evaluation of these tablets were done such as weight variation, hardness, friability, disintegration, drug-polymer interaction, FTIR studies, SEM studies, water content, drug content, water absorption ratio, wetting time and in-vitro drug release and short term stability studies. These tablets (all formulations that is F1-F10) showed weight variation in range of 253± 0.05 to 291± 0.61 mg, hardness of 2.1± 0.1 to 3.5± 0.07 Kg/cm², friability of 0.44±0.01 to 0.69±0.01%, disintegration time of 20± 0.08 to 34±1.1 seconds, drug content of 92.0 to 99.18%, water absorption ratio of 26±1.12 to 49 ± 3.01 %, wetting time of 53± 1.89 to 104± 4.89 sec and in-vitro drug release showed 85.66 to 99.88% within 5 minutes. FTIR studies showed that there is no interaction between drug and polymer. Stability studies showed that there is no change in drug release upon storage on different temperature and humidity. Results revealed that orally dispersible tablets of Chlorpheniramine maleate prepared by fusion method result in rapid dissolution. en_US
dc.language.iso eng en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Chlorpheniramine maleate, Fusion method, FTIR, SEM, Full factorial design en_US
dc.title Formulation and evaluation of orally dispersible tablets of Chlorpheniramine Maleate by fusion method en_US
dc.type article en_US
dc.relation.journal Marmara Pharmaceutical Journal en_US
dc.identifier.volume 21 en_US
dc.identifier.issue 1 en_US
dc.identifier.startpage 67 en_US
dc.identifier.endpage 77 en_US


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