Marmara Üniversitesi Açık Arşiv Sistemi

Non-aqueous emulsions as vehicles for capsule fillings

Basit öğe kaydını göster Bauer, Karl Dortunç, Betül 2018-03-12T10:14:41Z 2018-03-12T10:14:41Z 1984
dc.description.abstract New vehicles were developed based on non-aqueous emulsions. They may be classified as progress or supplimentation to the actual respectively conventional filling masses for soft gelatin capsules, but also for liquid or semi-solid hard gelatin capsule filling techniques. IN-VITRO dissolution rate studies exhibit a clear superiority of PEG filling masses about oil-wax bases, which show extremely slow release rates. These experiencies may therefore open an interesting way of attaining better bioavailabilities in certain cases with soft gelatin capsules as well as with hard gelatin capsules. But in the following corresponding IN-VIVO tests, which are carried out as urine recoveries, the whole loss of superiority of the PEG compounds is impressingly shown. On the contrary the PEG bases exhibit IN-VIVO the lowest recoveries, while the non-aqueous emulsions at least those with the Riboflavin indicate a tendency towards a more favorable gastrointestinal absorption. en_US
dc.language.iso eng en_US
dc.relation.isversionof en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.title Non-aqueous emulsions as vehicles for capsule fillings en_US
dc.type article en_US
dc.relation.journal Drug Development and Industrial Pharmacy en_US
dc.identifier.issue 5 en_US
dc.identifier.startpage 699 en_US
dc.identifier.endpage 712 en_US

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