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Methylenetetrahydrofolate reductase gene polymorphisms are associated with ischemic and hemorrhagic stroke

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dc.contributor.author Sazcı, Ali
dc.contributor.author Ergül, Emel
dc.contributor.author Tuncer, Neşe
dc.contributor.author Akpınar, Gürler
dc.contributor.author Kara, İhsan
dc.date.accessioned 2018-05-03T12:59:32Z
dc.date.available 2018-05-03T12:59:32Z
dc.date.issued 2006-12-11
dc.identifier.uri https://www.sciencedirect.com/science/article/abs/pii/S0361923006002425
dc.identifier.uri http://hdl.handle.net/11424/6544
dc.description.abstract Hyperhomocysteinemia is an independent risk factor for ischemic stroke. The enzyme methylenetetrahydrofolate reductase (MTHFR) plays a critical role in modulating the levels of plasma homocysteine. Two polymorphisms in the MTHFR gene, C677T, A1298C result in reduced enzyme activity. The mechanisms of ischemic and hemorrhagic stroke are not well understood. Although controversial, previous studies have shown evidence of causality of both stroke subtypes in patients with methylenetetrahydrofolate reductase gene polymorphisms. Therefore, we examined whether the C677T and A1298C polymorphisms of MTHFR gene are genetic risk factors for both ischemic and hemorrhagic stroke in a Turkish Caucasian population. In a case-control study, 120 total unrelated stroke patients (92 ischemic stroke, 28 hemorrhagic stroke), and 259 healthy controls were genotyped for C677T and A1298C polymorphisms of the MTHFR gene using a PCR-RFLP based-method. The MTHFR 1298C allele (chi(2) = 8.589; P=0.014), C1298C genotype (OR = 2.544; P=0.004), and C677C/C1298C compound genotype (OR = 3.020; P = 0.001) were associated with overall stroke. The MTHFR 1298C allele (chi(2) = 11.166; P=0.004), C1298C genotype (OR=2.950; P=0.001), and C677C/C1298C compound genotype (OR=3.463, P=0.0001) were strongly associated with ischemic stroke. Interestingly however, the MTHFR 677T allele (chi(2) =6.033; P=0.049), T677T genotype (OR=3.120; P=0.014), and T677T/AI298A compound genotype (OR=4.211; P=0.002) were associated with hemorrhagic stroke. In conclusion, the C677T and A1298C polymorphisms of the MTHFR gene are genetic risk factors for hamorrhagic and ischemic stroke respectively, independent of other atherothrombotic risk factors. (c) 2006 Elsevier Inc. All rights reserved. en_US
dc.language.iso eng en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject MTHFR; polymorphism; association; ischemic stroke; hemorrhagic stroke; Turkey en_US
dc.title Methylenetetrahydrofolate reductase gene polymorphisms are associated with ischemic and hemorrhagic stroke en_US
dc.title.alternative Dual effect of MTHFR polymorphisms C677T and A1298C en_US
dc.type article en_US
dc.relation.journal Braın Research Bulletın en_US
dc.identifier.volume 71 en_US
dc.identifier.issue 1-3 en_US
dc.identifier.startpage 45 en_US
dc.identifier.endpage 50 en_US


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