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dc.contributor.authorOral, Başak
dc.date.accessioned2014-07-18T13:29:13Z
dc.date.available2014-07-18T13:29:13Z
dc.date.issued2012
dc.identifier.issn1309-0801
dc.identifier.urihttp://dspace.marmara.edu.tr/handle/18832014/1479
dc.description.abstractNovel derivatives of substituted hydrazone (2a-e), 2-pyrazoline-5-one (3a-e, 4ae) and 2-isoxazoline-5-one (5a-e) derivatives possessing 1,3,4-thiadiazole moiety were synthesized and evaluated for their antitubercular activity. The highest inhibitions were observed with the synthesized compounds are 87% for 3-methyl-4-[4-(5-cyclohexylamino- 1,3,4-thiadiazole-2-yl)phenylhydrazono]-2-isoxazoline-5-one (5b) and 86% for ethyl 2-[4-(5-cyclohexylamino-1,3,4-thiadiazole-2-yl)phenylhydrazono]-3-oxobutirate (2b). Compounds 2b and 5b could be a good initial point to develop new lead compound.en_US
dc.language.isoenen_US
dc.publisherMarmara Pharmaceutical Journalen_US
dc.subject1,3,4-thiadiazole, 2-pyrazolin-5-one, 2-isoxazoline-5-one, hydrazone and antitubercular activityen_US
dc.titleThe synthesis and antitubercular activity of substituted hydrazone,2-pyrazoline-5- one and 2-isoxazoline-5-one derivatives possessing 1,3,4-thiadiazole moietyen_US
dc.typeArticleen_US
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