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dc.contributor.authorEkmekçi, Abdullah
dc.contributor.authorKonaç, Ece
dc.contributor.authorÖnen, H. İlke
dc.date.accessioned2014-08-07T12:22:18Z
dc.date.available2014-08-07T12:22:18Z
dc.date.issued2008
dc.identifier.issn1309-9469
dc.identifier.urihttp://hdl.handle.net/11424/2272
dc.description.abstractMain genetic factors which may increase the risk of cancer are genetic disorders (mutations), genetic differences which affect the structures and expression levels (carcinogenic metabolism) of enzymes that activate and detoxificate chemicals and polymorphic/genetic changes which affect the capacity to repair DNA damage. Polymorphisms are observed more frequently than the mutations. A gene polymorphism is defined as the occurrence of genetic variants or gene alternative forms in frequencies higher than 1 percent. Single nucleotide polymorphisms (SNPs) are the most observed genetic variants in human genome. Presence of thousands of polymorphic genes in the genome and the fact that the genome may affect the susceptibility of individuals with these variants to development of cancer lead many researchers to explore this uncharted study area.en_US
dc.language.isoenen_US
dc.publisherMarmara Medical Journalen_US
dc.subjectApoptosis, DNA Repair, Cell Cycle, Cancer, Metastasis, Polymorphismen_US
dc.titleGene polymorphism and genetic susceptibility to canceren_US
dc.typeArticleen_US


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