Solid organ (kidney, liver, pancreas-kidney, heart, lung and heart-lung) transplantations and pregnancy
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The frequency and variety of solid organ transplantation in reproductive-age women increases each year. Although most transplant-related pregnancies have been reported in women with kidney allografts, pregnancy is also possible in young women with other solid organ transplants including liver, pancreas-kidney, heart, lung and heart-lung transplants. Most of these pregnancies have resulted in a successfull outcome; however, for optimal maternal and neonatal outcomes, a multidisciplinary approach including careful follow-ups of the obstetrician and transplant team is essential. This article reviews and discusses preconceptional counselling, graft rejection and dysfunction during pregnancy, safety of immunosuppressive medications with regard to fetus, and perinatal risks and pregnancy management for women with various solid organ transplants, taking into consideration previous published reports, especially The National Transplantation Pregnancy Registry (NTPR)’s.