The effect of endocannabinoid system on energy metabolism and obesity
Tüfekçi Alphan, Emel
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Recently, it has been defined that Marijuana and its major psychotropic component which Δ9-tetrahydrocannabinol, CB1 cannabinoid receptors and endocannabinoids which include endogenous ligands stimulate appetite and increase body weight by controlling energy balance. It has been shown on the animal experiments and human clinical studies that the endocannabinoid system controls food intake by central and peripheral mechanism and stimulate lipogenesis and fat accumulation. The formation of endocannabinoid system and its receptors, ligands and energy metabolism of this physiological system and the effect on energy metabolism have been discussed at the article.