Show simple item record

dc.contributor.authorTürker, Gülcan
dc.contributor.authorAydoğan, Ayşen
dc.contributor.authorSarper, Nazan
dc.contributor.authorDuman, Can
dc.contributor.authorArısoy, A. Engin
dc.contributor.authorÇorapcıoğlu, Funda
dc.date.accessioned2014-09-30T15:37:37Z
dc.date.available2014-09-30T15:37:37Z
dc.date.issued2004
dc.identifier.issn1309-9469
dc.identifier.urihttp://hdl.handle.net/11424/3207
dc.description.abstractObjective: Alpha fetoprotein (AFP) is an important tumor marker in childhood. However, AFP levels remain high during the first few months of life, making clinical interpretation difficult in this period. The aim of the present study is to determine normal AFP levels in healthy full-term neonates and infants followed-up at Kocaeli University Hospital, Department of Pediatrics. Materials and Methods: Healthy full-term neonates born in Kocaeli University Hospital and <12 month-old infants attending the well baby outpatient clinic were enrolled in the study. Blood samples were drawn from the umbilical cord vein at delivery or peripheral vein after delivery. Serum AFP concentration was determined by solid phase, two-site chemiluminescent immunometric commercial diagnostic assay. Results: Ninety-four neonates with a gestational age of 37-41 weeks and <12 month-old infants (48 male, 46 female) were enrolled. Mean AFP level of cord blood samples was 67.246±52.137 (105-226.000) ng/ml. Serum AFP levels of all 94 babies had a significant negative correlation with the postnatal age (r=-0.877, p<0.001). Results of regression analyses did not support a significant sex dependency (r= -.096, p=0.35). Conclusion: Normal range of AFP in healthy full-term neonates and infants is very wide. Pediatric oncologists must consider moderately high values carefully in the follow-up period and if the decrease in the follow-up measurement is slower than the expected half-life for that age, the probability of an AFP-producing tumor could be high. This approach would prevent unnecessary interventions depending on false positive AFP results.en_US
dc.language.isoenen_US
dc.publisherMarmara Medical Journalen_US
dc.subjectAlpha fetoprotein, Normal range, Newborns, Infantsen_US
dc.titleSerum alpha fetoprotein levels in healthy full-term neonates and infantsen_US
dc.typeArticleen_US
dc.contributor.authorIDTR1528en_US
dc.contributor.authorIDTR146760en_US
dc.contributor.authorIDTR31577en_US
dc.contributor.authorIDTR187113en_US
dc.contributor.authorIDTR153518en_US
dc.contributor.authorIDTR125402en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record