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dc.contributor.authorÖğülür, İsmail
dc.date.accessioned2016-03-04T19:18:19Z
dc.date.available2016-03-04T19:18:19Z
dc.date.issued2016
dc.identifier.issn18716784
dc.identifier.urihttp://tinyurl.com/ze4ncy5
dc.identifier.urihttp://hdl.handle.net/11424/4247
dc.description.abstractBacillus subtilis has the capacity to produce more than two dozen bioactive compounds with an amazing variety of chemical structures. Among them, bacilysin is a non-ribosomally synthesized dipeptide antibiotic consisting of l-alanine residue at the N terminus and a non-proteinogenic amino acid, l-anticapsin, at the C terminus. In spite of its simple structure, it is active against a wide range of bacteria and fungi. As a potent antimicrobial agent, we briefly review the biochemistry and genetics as well as the regulation of bacilysin biosynthesis within the frame of peptide pheromones-based control of secondary activities. Biological functions of bacilysin in the producer B. subtilis beyond its antimicrobial activity as well as potential biotechnological use of the biosynthetic enzyme l-amino acid ligase (Lal) are also discussed. © 2015 Elsevier B.V.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1016/j.nbt.2015.01.006en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.titleBiochemistry, genetics and regulation of bacilysin biosynthesis and its significance more than an antibioticen_US
dc.typearticleen_US
dc.contributor.authorIDTR222730en_US
dc.relation.journalNew Biotechnologyen_US
dc.contributor.departmentResearch and Training Hospital, Division of Pediatric Allergy and Immunology,Marmara Universityen_US
dc.identifier.volume32en_US
dc.identifier.issue6en_US
dc.identifier.startpage612en_US
dc.identifier.endpage619en_US


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