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dc.contributor.authorBingöl Özakpınar, Özlem
dc.contributor.authorUras, Fikriye
dc.date.accessioned2016-03-23T17:19:04Z
dc.date.available2016-03-23T17:19:04Z
dc.date.issued2015
dc.identifier.issn01969781
dc.identifier.urihttp://tinyurl.com/jkxzxso
dc.identifier.urihttp://hdl.handle.net/11424/4312
dc.description.abstractOxytocin (OXY) plays a crucial role in reproduction. The aim of this study is to investigate the therapeutic and protective effects of oxytocin treatment on streptozotocin (STZ) induced diabetes in testicular tissue. The rats were randomly divided into four experimental groups: (I) Control Group, (II) STZ induced Diabetic Group (STZ Group), (III) STZ induced Diabetic Group with Pre-Oxytocin treatment (Pre-OXY Group) and (IV) STZ induced Diabetic Group with Post-Oxytocin treatment (Post-OXY Group); each group contains six animals. The rats whose blood glucose levels were more than 200 mg/dl were included to the experiment. At the end of the 4th week, testes tissue samples were taken to be processed for light microscopy and transmission electron microscopy. Malondialdehyde (MDA), Glutathione (GSH) and Advanced Oxidation Protein Products (AOPP) levels were determined biochemically in blood samples. Testicular tissue samples stained with Hematoxylin and Eosin (H&E) and Periodic acid-Schiff (PAS) reaction were evaluated under light microscope. The histopathological damage score of testicular tissue, which was significantly increased in STZ group, was decreased by oxytocin treatment. According to biochemical data, MDA and AOPP levels have been increased in the blood of STZ Group compared to the Control Group whereas they decreased significantly in Oxytocin-treated Groups compared to STZ Group. GSH levels were significantly decreased in the blood of STZ Group and increased in the blood of Oxytocin-treated Groups compared to STZ Group. In conclusion, oxytocin has a potential protective effect on the testes tissue of STZ-induced diabetic rats. © 2014 Elsevier Inc.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1016/j.peptides.2014.10.012en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectDiabetes; Infertility; Oxidative stress; Oxytocin; STZ; Testesen_US
dc.titleThe effect of exogenous oxytocin on streptozotocin (STZ)-induced diabetic adult rat testesen_US
dc.typearticleen_US
dc.contributor.authorIDTR122459en_US
dc.contributor.authorIDTR7855en_US
dc.relation.journalPeptidesen_US
dc.contributor.departmentMarmara University, School of Pharmacy, Biochemistry Departmenten_US
dc.identifier.volume63en_US
dc.identifier.startpage47en_US
dc.identifier.endpage54en_US


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