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dc.contributor.authorDirican, Ebubekir
dc.date.accessioned2016-05-08T12:50:10Z
dc.date.available2016-05-08T12:50:10Z
dc.date.issued2014
dc.identifier.issn09209069
dc.identifier.urihttp://goo.gl/YsLe0R
dc.identifier.urihttp://hdl.handle.net/11424/4521
dc.description.abstractCadmium is a modern environmental contaminant that is toxic and carcinogenic. Glycyrrhiza glabra is a traditional medicinal herb which grows in the various parts of the World. Recent studies demonstrated that G. glabra has antifungal, antimicrobial, antioxidant, and powerful antiinflammatory features. The purpose of this study was to investigate the genetic safety of extracts from G. glabra and its effects on cadmium (as CdCl2) induced genotoxicity. Therefore we evaluated the capability of G. glabra extract to inhibit the rate of micronucleus (MN), sister chromatid exchange (SCE) formations induced by CdCl2. Moreover, to assess the effects of G. glabra on cell viability and oxidative status, we performed 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and total antioxidant capacity (TAC) assays. Our results showed that there were significant increases (P < 0.05) in both SCE and MN frequencies of cultures treated with CdCl2 (5 ppm) as compared to controls. However, co-application of G. glabra extract (5, 10 and 20 ppm) and CdCl2 resulted in decreases of MN and SCE rates as compared to the group treated with CdCl2 alone. Again, the results of MTT and TAC assays clearly indicated dose dependent ameliorative effects of G. glabra extracts against CdCl2 toxicity. In conclusion, this study demonstrated for the first time that G. glabra extracts provided increased resistance of DNA against CdCl2 induced genetic and oxidative damage in human lymphocytes. So, the risk on target tissues of CdCl2 could be reduced and ensured early recovery from its toxicity. © 2013 Springer Science+Business Media Dordrecht.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1007/s10616-012-9531-5en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectCadmium; Genotoxicity; Glycyrrhiza glabra; Human lymphocytes; Oxidative stress; Protective effecten_US
dc.titleIn vitro studies on protective effect of Glycyrrhiza glabra root extracts against cadmium-induced genetic and oxidative damage in human lymphocytesen_US
dc.typearticleen_US
dc.relation.journalCytotechnologyen_US
dc.contributor.departmentDepartment of Medical Biology, Medical Faculty, Marmara Universityen_US
dc.identifier.volume66en_US
dc.identifier.issue1en_US
dc.identifier.startpage9en_US
dc.identifier.endpage16en_US


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