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dc.contributor.authorBaş Bozkurtlar, Emine
dc.contributor.authorKaya, Handan
dc.contributor.authorTelli, Ferhat
dc.contributor.authorTurhal, Nazım Serdar
dc.contributor.authorFulden Yumuk, Perran
dc.date.accessioned2016-05-12T06:15:25Z
dc.date.available2016-05-12T06:15:25Z
dc.date.issued2014
dc.identifier.issn11070625
dc.identifier.urihttp://goo.gl/SuYJUF
dc.identifier.urihttp://hdl.handle.net/11424/4545
dc.description.abstractPurpose: Although the clinical benefits of trastuzumab are well known, intrinsic or acquired resistance is a commonly encountered clinical condition. A potential resistance mechanism is aberrant downstream signal transmission due to loss of phosphatase and tensine homologue (PTEN). This study investigated the relationship between trastuzumab response and loss of PTEN in metastatic breast cancer patients. Methods: Patients with histologically confirmed human epidermal growth factor receptor 2 (HER2) positive metastatic breast cancer, who were treated with trastuzumab were enrolled into the study. PTEN expression was immunohistochemically evaluated. Results: The patient median age was 50 years. Of 38 patients, 6 (15.8%) showed PTEN loss. No statistically significant difference was found between trastuzumab response, overall survival (OS) and progression-free survival (PFS) and PTEN loss (p=0.538). Conclusion: The activation of phosphatidylinositol 3-kinase (PI3K) pathway resulting from PTEN loss was not found to be correlated with trastuzumab response and survival. PTEN loss should not lead to exclusion of patients from the potential to benefit from trastuzumab administration.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectBreast cancer; HER2; PI3K pathway; PTEN loss; Trastuzumaben_US
dc.titlePTEN loss is not associated with trastuzumab resistance in metastatic breast canceren_US
dc.typearticleen_US
dc.contributor.authorIDTR3127en_US
dc.contributor.authorIDTR173293en_US
dc.relation.journalJournal of B.U.ON.en_US
dc.contributor.departmentDepartment of Pathology, Marmara Hospitalen_US
dc.identifier.volume19en_US
dc.identifier.issue4en_US
dc.identifier.startpage900en_US
dc.identifier.endpage905en_US


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