Clınıcal sıgnıfıcance of antıperınuclear factor and antıkeratın antıbody for rheumatoıd arthrıtıs
Rheumatoid Factor (RF) is the only serologic marker used in the diagnosis of rheumatoid arthritis (RA). Since it is present in a number of diseases other than RA and found negative in some patients with RA, diagnostic utility of RF has some limitations. Several more specific autoantibodies detected in the sera of RA patients are not routinely tested. Antiperinuclear factor (APF) and antikeratin antibodies (AKA) are two of these antibodies. In previously reported series, the APF was present in 49% and 87% of RA patients with a specificity between 73% and 99%. AKA was detected positive in 36% to 59% of the RA patients, and its specificity was 88% to 99. In this article, we have reviewed characteristics, significance in the pathogenesis and the diagnostic use of these two antibodies in RA.