Estrogen modulating effects of resveratrol in female rats
Özatik, Fikriye Yasemin
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This study investigates the estrogen-like effects of resveratrol (RES) in female rats. Materials and Methods: In this two-step study on estrogenlike activity of RES, immature female rats (21 days old) were used in the first step and pubertal female rats (28 days old) with primary ovarian failure (POF) induced by 4-vinylcyclohexene diepoxide (VCD) were used in the second step. Possible agonistic and/or antagonistic effects of RES were investigated by using several parameters including the ratios of uterine/body weights (UBW), uterine dry/wet weights (UDWW) and body weight increase (BW%), bone density measurement, serum estradiol and vitamin D levels and histological evaluation.