Formulation design and ın vitro evaluation of carbamazepine gastroretentive floating drug delivery system for oral application
Bhuiyan, Masud Kaisar
HOSSAIN, Mohammad Salim
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The aim of the study was to investigate the uses of hydrophilic polymers i.e. Methocel K4M and Carbomer 971 to develop a gastroretentive floating drug delivery system containing Carbamazipine as a model drug. The effect of the polymers was evaluated in terms of physical characteristics, swelling properties, floating behavior and drug release profile. Floating lag time was found to be 4-136 sec and total floating time was 6-18 h depending on the formulations. Drug release was studied for 8 h. Simulated drug release pattern in different kinetic model suggests that the mechanism controlling of the drug release from all formulations was the anomalous or non-Fickian. Along with more swelling capacity, carbopol 971 was able to retard the drug release more effectively than that of Methocel K4M based matrix.