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dc.contributor.authorTÜRK, Sevda
dc.contributor.authorTOK, Fatih
dc.contributor.authorÇELİK, Hülya
dc.contributor.authorKARAKUŞ, Sevgi
dc.contributor.authorNADAROĞLU, Hayrunnisa
dc.contributor.authorKOÇYİĞİT-KAYMAKÇIOĞLU, Bedia
dc.contributor.authorKÜÇÜKOĞLU, Kaan
dc.date.accessioned2017-02-24T08:39:37Z
dc.date.available2017-02-24T08:39:37Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/11424/5279
dc.description.abstractIn the present study, N-(5-methyl-1,3,4-thiadiazol-2-yl)- 4-[(3-substituted)ureido]benzenesulfonamide (1-9) and N-(5-methyl-1,3,4-thiadiazol-2-yl)-4-[(3-substituted) thioureido]benzenesulfonamide (10-14) derivatives were synthesized from 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl) benzenesulfonamide (sulfamethizole). All new compounds were characterized by elemental analysis and various spectroscopic methods (FTIR, 1 H-NMR and MS). These new sulfonamide derivatives were investigated as inhibitors of carbonic anhydrase especially human carbonic anhydrase I and II. The new compounds showed higher activity against the human cytosolic CA I (IC50 values 0.144-15.65 nM) and CA II (IC50 values 0.109- 17.95 nM) in comparison with the clinically used CA inhibitor acetazolamideen_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarbonic anhydrase inhibitors, sulfonamide, sulfamethizole, urea and thioureaen_US
dc.titleSome N-(5-methyl-1,3,4-thiadiazol-2-yl)-4-[(3-substituted)ureido/ thioureido]benzenesulfonamides as carbonic anhydrase I and II Inhibitorsen_US
dc.typearticleen_US
dc.contributor.authorIDTR53043en_US
dc.contributor.authorIDTR108086en_US
dc.contributor.authorIDTR181749en_US
dc.contributor.authorIDTR172613en_US
dc.contributor.authorIDTR24199en_US
dc.contributor.authorIDTR48361en_US
dc.contributor.authorIDTR171592en_US
dc.relation.journalMarmara Pharmaceutical Journalen_US
dc.identifier.volume21en_US
dc.identifier.issue1en_US
dc.identifier.startpage89en_US
dc.identifier.endpage95en_US


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