Show simple item record

dc.contributor.authorUlusoy, Nuray
dc.contributor.authorGürsoy, Elif
dc.date.accessioned2017-02-27T07:52:52Z
dc.date.available2017-02-27T07:52:52Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/11424/5281
dc.description.abstractNew N’-(arylidene)-2-[6-(4-bromophenyl)imidazo[2,1-b] thiazol-3-yl]acetohydrazides (3a-i) were synthesized by reacting 2-[6-(4-bromophenyl)imidazo[2,1-b]thiazol-3-yl] acetohydrazidewith different aromatic aldehydes. The structures of the title compounds were established by spectral data (IR, 1 H NMR, 13C NMR) and elemental analyses. The synthesized compounds were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv employing the BACTEC 460 radiometric system. The compounds exhibited varying degrees of inhibition in the in vitro primary screening that was conducted at a concentration of 6.25 mg/ml. Among the synthesized compounds [6-(4-bromophenyl)imidazo[2,1-b] thiazol-3-yl]acetic acid 2,4-dinitrobenzylidenehydrazide (3e) was found to be the most active compound in vitro with MIC of 6.25 mg/ml.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectImidazo[2,1-b]thiazole, hydrazone, antimycobacterial activityen_US
dc.titleSynthesis and evaluation of new imidazo[2,1-b]thiazoles as antituberculosis agentsen_US
dc.typearticleen_US
dc.relation.journalMarmara Pharmaceutical Journalen_US
dc.identifier.volume21en_US
dc.identifier.issue1en_US
dc.identifier.startpage102en_US
dc.identifier.endpage109en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record