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dc.contributor.authorON, Shamsul
dc.contributor.authorSALLEH, Wan Mohd Nuzul Hakimi Wan
dc.contributor.authorAHMAD, Farediah
dc.contributor.authorSIRAT, Hasnah Mohd
dc.contributor.authorTAHER, Muhammad
dc.date.accessioned2017-02-27T08:06:43Z
dc.date.available2017-02-27T08:06:43Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/11424/5284
dc.description.abstractPhytochemical investigation of the leaves of Garcinia prainiana resulted in the isolation of five triterpenes identified as squalene 1, friedelin 2, lupeol 3, 3β-hydroxyeupha-5,22-diene 4, and 3β-acetoxyeupha-5,22-diene 5. The structures of these compounds were established by analysis of their spectroscopic data, as compared to that of reported compounds. All compounds were tested for cytotoxicity against H1299 and A549 lung cancer cell lines using MTT assay. 3β-Acetoxyeupha-5,22- diene 5 exhibited the most significant activity against human non-small cell lung carcinoma cell lines, H1299 and A549 with IC50 values 18.0 µg/mL and 36.3 µg/mL, respectively.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTriterpene, Garcinia prainiana, Cytotoxicityen_US
dc.titleCytotoxicity of triterpenes from the leaves of Garcinia prainiana King (Guttiferae)en_US
dc.typearticleen_US
dc.relation.journalMarmara Pharmaceutical Journalen_US
dc.identifier.volume21en_US
dc.identifier.issue1en_US
dc.identifier.startpage127en_US
dc.identifier.endpage131en_US


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