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dc.contributor.authorTarikoğulları, Ayşe H.
dc.contributor.authorÇizmecioğlu, M. Murat
dc.contributor.authorSayla, Merve
dc.contributor.authorParlar, Sülünay
dc.contributor.authorAlptüzün, Vildan
dc.contributor.authorSoyer, Zeynep
dc.date.accessioned2017-03-01T06:37:22Z
dc.date.available2017-03-01T06:37:22Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/11424/5320
dc.description.abstractA group of N-phenylacetamide derivatives bearing five membered heterocyclic rings, pyrazole or 1,2,4-triazole, were synthesized to investigate their cholinesterase inhibitory activities. Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities were evaluated by using Ellman’s spectroscopic method. Results indicated that all of the compounds displayed moderate and selective AChE inhibitory activity and the most active compound was 2-(1H-1,2,4-triazole-1-yl)-N-(3-methoxyphenyl)acetamide with an IC50 value of 6.68 mM. Docking studies were also carried out for the most active compounden_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlzheimer’s disease, pyrazole, 1,2,4-triazole, acetamide, cholinesterase inhibitory activityen_US
dc.titleSynthesis and cholinesterase inhibitory activity of some phenylacetamide derivatives bearing 1H-pyrazole or 1H-1,2,4-triazoleen_US
dc.typearticleen_US
dc.contributor.authorIDTR42498en_US
dc.contributor.authorIDTR232789en_US
dc.contributor.authorIDTR162478en_US
dc.contributor.authorIDTR47821en_US
dc.contributor.authorIDTR47637en_US
dc.relation.journalMarmara Pharmaceutical Journalen_US
dc.identifier.volume20en_US
dc.identifier.issue1en_US
dc.identifier.startpage21en_US
dc.identifier.endpage27en_US


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